Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.
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چکیده
منابع مشابه
Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.
BACKGROUND Endothelium-dependent vasodilation is abnormal in experimental models of diabetes mellitus. We postulated that abnormalities of endothelial function are also present in patients with insulin-dependent diabetes mellitus and may contribute to the pathogenesis of vascular disease in these individuals. METHODS AND RESULTS Vascular reactivity was measured in the forearm resistance vesse...
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OBJECTIVES We sought to determine whether the antioxidant vitamin C improves endothelium-dependent vasodilation of forearm resistance vessels in patients with insulin-dependent diabetes mellitus. BACKGROUND Endothelium-dependent vasodilation is impaired in patients with diabetes mellitus. Oxidatively mediated degradation of endothelium-derived nitric oxide contributes to abnormal endothelium-...
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Endothelium-dependent vasodilation is impaired in humans with diabetes mellitus. Inactivation of endothelium-derived nitric oxide by oxygen-derived free radicals contributes to abnormal vascular reactivity in experimental models of diabetes. To determine whether this observation is relevant to humans, we tested the hypothesis that the antioxidant, vitamin C, could improve endothelium-dependent ...
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ژورنال
عنوان ژورنال: Circulation
سال: 1993
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.88.6.2510